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Survey of Physical Science (GC 207)

Term: 2024-2025 Summer

Faculty

Carlos da Silva
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Carlos Aparecido da Silva Junior was born on March 20th, 1995, in Serrana, São Paulo, Brazil. He received a Teaching Degree (Licentiate) and a Bachelor in Biological Science from the São Paulo State University, in 2016 and 2017, respectively. He was recognized twice as the best ranked student of his graduation class. Later, he started his master program in Physiological Sciences at the Federal University of São Carlos in partnership with São Paulo State University, in the Interinstitutional Graduate Program in Physiological Sciences. He completed his master in August 2020. In parallel, he worked as a science teacher for public, private, and vocational schools. While as a master student, he was granted an international fellowship from the São Paulo Research Foundation and developed a 6-month project in Christopher Del Negro’s lab, at William & Mary, Williamsburg, VA, in 2019. After concluding his studies in Brazil, he began his doctoral program in the Department of Applied Science in Fall 2020 under the supervision of Christopher A. Del Negro. Concurrently, he taught Human Anatomy & Physiology classes at Christopher Newport University, Newport News, VA. He earned his Ph.D. in June 2024. His research has focused on the neural control of breathing, studying the exogenous factors that influence the normal development of the respiratory network, the underlying ion channel mechanisms for inspiratory rhythm generation, as well the mechanisms for inspiratory burst termination.  

 

Publications  

  • da Silva Junior, C.A., Grover, C.J., Picardo, M.C.D., Del Negro, C.A. (2023). Role of NaV1.6-mediated persistent sodium current and bursting-pacemaker properties in breathing rhythm generation. Cell Reports, 42. https://10.1016/j.celrep.2023.113000.
  • da Silva Junior, C.A., Marques, D.A., Patrone, L.G.A., Biancardi, V., Bícego, K.C., Gargaglioni, L.H. (2023). Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience letters, 795. https://doi.org/10.1016/j.neulet.2022.137014. 
  • da Silva Junior, C.A., Patrone, L.G.A., Biancardi, V., Vilela-Costa, H.H., Marques, D.A., Cristina-Silva, C., da Costa Silva, K.S., Bícego, K.C., Szawka, R.E., Gargaglioni, L.H. (2022). Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats. Pflugers Arch. 474 (11), 1185-1200. https://doi.org/10.1007/s00424-022-02730-7.
  • da Silva Junior, C.A., Picardo, M.C., Del Negro, C. (2022). RNA interference via shRNA decreases the number of transcripts of Scn8a in glutamatergic interneurons in the preBötC. The FASEB Journal, 36. https://doi.org/10.1096/fasebj.2022.36.S1.R2948. 
  • da Silva Junior, C.A., Biancardi, V., Patrone, L.G.A., Bícego, K.C. and Gargaglioni, L.H. (2020). Intra-uterine exposure to Diazepam decrease the ventilatory response and impairs the motor behavior of males and females at post-natal life. The FASEB Journal, 34. https://doi.org/10.1096/fasebj.2020.34.s1.06981.
  • Leirão, I. P., Silva, C. A. Jr, Gargaglioni, L. H., da Silva, G. (2018). Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats. The Journal of Physiology, 596 (15), 3271–3283. https://doi.org/10.1113/JP274726.
  • Augusto, T. G. da S., Silva Junior, C. A. (2020). A trajetória do sangue no corpo humano: a história da ciência na formação continuada de professores de biologia. [EN: The path of blood in the human body: history of science in the training of in-service biology teachers]. Revista Brasileira de História Da Ciência, 13 (2), p. 250-260. https://doi.org/10.53727/rbhc.v13i2.37.
  • Silva, C. A., Vicente, M. C., Tenorio-Lopes, L., Soliz, J., Gargaglioni, L. H. (2017). Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats. Respiratory physiology & neurobiology, 236, 11–18. https://doi.org/10.1016/j.resp.2016.10.011.
  • da Silva Junior, C. A., G. da S. A. Thaís. (2017). História Das Ideias Sobre circulação sanguínea: Concepções De Professores De Biologia. [EN: The history of the Blood Circulation: Conceptions of Biology Teachers]. Enseñanza De Las Ciencias: Revista De investigación Y Experiencias didácticas, Extra, 3007-12. https://raco.cat/index.php/Ensenanza/article/view/339797 

Description

A course introducing the nature and origin of matter, energy, and physical processes. Included is a general overview of geology, astronomy, meteorology, and environmental concerns. (The math requirement should be completed before or taken concurrently with GC207. Lab required.)